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Schiller Laboratory of Affective Neuroscience

Thank you for your interest in our study! The purpose of this study is to better understand misophonia, a condition in which auditory triggers lead to strong physical and emotional responses. This study will take place at the Icahn School of Medicine at Mount Sinai and will involve two in-person separate visits and two remote sessions and potentially taking propranolol, a common drug used to treat high blood pressure and can be used for relieving stage fright.

During the first, you will listen to misophonia cue sounds. Next, you will take either a propranolol or a placebo tablet, which has the same appearance as the propranolol tablet but does not contain any propranolol. Neither you nor the study coordinator will choose what experimental study treatment you get. You will have an equal chance of being given each experimental treatment. You will then answer a series of survey questions and play computer games that are designed to assess aspects of your personality, behavior, and mood. We may measure your body's response through galvanic skin response (GSR). This first session should last approximately two hours.

For the second session that occurs six hours later, you will once again answer a series of survey questions and play computer games that are designed to assess aspects of your personality, behavior, and mood. Again, we may record your body's response with GSR. This second session should last approximately 30 min.

For the remote third and fourth session 1 week to 1 month later, you will repeat the same survey questions and computer games with GSR. This third and fourth session should last approximately 30 min.

Before we invite you to Mount Sinai, we need to make sure that you are eligible to participate in this study. We have listed several conditions below that would prevent you from participating. After reading through the list, if you believe you are eligible to participate, please contact us by replying to this email (Alissa.chen@mssm.edu) or by calling the phone number (631-772-9464) and we will schedule a time for your first visit. Please do not provide us with your responses to the prompts below. Upon arriving at Mount Sinai, we will ask you further questions, meeting the criteria below does not guarantee your participation in this study. There is still a chance that we will determine that you are ineligible.

Eligibility Criteria

Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear.
Must be between the ages of 18 - 55.
Must be fluent in English since the study's instructions, surveys, and tasks will be in English

Exclusion Criteria for those willing to take propranolol

Disability or medical condition that prohibits completion of study. Participants must be able to complete all study procedures to ensure optimal conditions for data analysis.
CNS disease, such as history of brain abnormalities (e.g., neoplasms, subarachnoid cysts), cerebrovascular disease, infectious disease (e.g., absess), or other neurological disease, history of head trauma (defined as loss of consciousness>3 min), or history of seizures without a resolved etiology. CNS disease and drugs that act in the peripheral or central nervous system are likely to have effects on patterns of neural activity.
Recently used drugs of abuse.
Pregnancy. The risks associated with neither propranolol exposure during gestation have been studied extensively.
Lactation. Propranolol is excreted in human breast-milk, and its impact on infant development has not been studied.
Regular use of medication metabolized in the CYP2D6, 1A2, or 2C19 pathways. Drugs that are metabolized in the same pathway as propranolol may increase its efficacy or toxicity. Please continue filling out the form if unsure, and we can help determine.
Blood pressure over 150/100 or under 100/60 (applicable for either systolic or diastolic measures) and any hypertension requiring medication. Propranolol is known to pose additional risk to individuals with a number of medical conditions.
Pulse over 100 or under 60.
History of cardiovascular illness such as cardiac arrhythmia, coronary heart disease or any cardiac dysfunction that requires medication.
Active respiratory illness including bronchospastic pulmonary disease and chronic obstructive pulmonary disease
Diabetes meillitus.
Other medical conditions that make it unsafe to take propranolol (e. g. allergy to propranolol).

Please read through the lists above thoroughly. If you believe you are eligible to participate in this study, please provide your phone number and email and we will be in touch with you shortly.

Please do not provide us with your responses to the prompts above. We look forward to getting in touch!

Phone number:

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Email:

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Where did you find our ad?
(ie. Friend, Flyer on 99th and Madison, r/misophonia reddit, "Misophonia Support Group" Facebook Group, SoQuiet research pool)

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Please indicate your availability here (ie. Mondays after 3pm, Tuesdays from 12-1pm).
We're available 9am-5pm Mon-Fri.
Please give us 3 business days to get back to you!

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